9,11-Cyclic acetal derivatives of (9S)-9-dihydroerythromycin A.
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چکیده
منابع مشابه
Gold-catalyzed cyclization of allenyl acetal derivatives
The gold-catalyzed transformation of allenyl acetals into 5-alkylidenecyclopent-2-en-1-ones is described. The outcome of our deuterium labeling experiments supports a 1,4-hydride shift of the resulting allyl cationic intermediates because a complete deuterium transfer is observed. We tested the reaction on various acetal substrates bearing a propargyl acetate, giving 4-methoxy-5-alkylidenecyclo...
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Clarithromycin1* (1, 6-O-methylerythromycin A, A-56268, TE-031) is a new macrolide currently undergoing clinical development. The excellent properties2) of 1 make it attractive for further synthetic modifications. It is knownthat, reduction of the 9-keto group of erythromycin A (2), for example with sodium borohydride, gives the corresponding secondary alcohol, predominantly as the 9(S) epimer,...
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T E X A S A. AND M. C O L L E G E , ) College Station, Texas, I March 26, 1901. ) Dear Prof. Edwards : — I often notice your request for news from former students and alumni of old M. A . C , but, like many others, I have more often than otherwise been content with a perusal of the welcome news in the R E C O R D each week and failed to send the requested items. The first column that engages ou...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1989
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.42.293